phenol toxicity in cats

Even dilute solutions (1% to 2%) may cause severe burns if contact is prolonged. Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means also 300 ppm of phenol per day and 344 ppm of m-cresol. Diagnosis of phenol and phenolic poisoning is either on a rule out basis or by witnessing it firsthand. The symptoms he may display are not commonly seen in anything other than a type of toxicity. Similarity of these genes with mammalian genes is <50%, and … The Committee took note of the ADI of 0-0.4 mg/kg bw for 2-phenylphenol (No. While most cases 2/7. Comments. RELEVANT BACKGROUND INFORMATION 2.1 Explanation. Phenol poisoning in the cat. 100%), the greater the risk to the cat. Here are Some Essential Oils that are Safe to Diffuse around Cats Some of these essential oils are void of the organic compound phenol and if any is however present, then it must have reduced in terms of its concentration to a level where it is bearable for cats.. Cedarwood Essential Oil. But in cats, it can even cause severe liver disease or liver failure. Common drugs such as non-steroidal anti-inflammatories are some of the most deadly to cats. Primarily, the values are clustered in the range 250–500 mg/kg, although the value Hot oils like cinnamon, nutmeg, and thyme contain the highest levels of phenol and can be the most offensive to cats. This enzyme protects animals from toxins or harmful substances like those scents from essential oil. 100%), the greater the risk to the cat. Food poisoning is another common cause of poisoning in cats. 735) established by the 1999 Joint FAO/WHO Meeting on Pesticide Residues (FAO, 1999). Acute keratoconjunctivitis sicca has been reported in some dogs after acetaminophen ingestion. Top Cat. ERNST MR, KLESMER R, HUEBNER RA, MARTIN JE. 1. Berjé is a family-owned business that has been in operation for six decades. Susceptibility of cats to phenol. It is a weak acid derived from phenol. Phenol poisoning can occur by skin absorption, vapor inhalation, or ingestion, and, regardless of route of exposure, can result in det rimental health effects. Cats are deficient in an enzyme called glucuronyl transferase, which can be found in the liver and is responsible for breaking down Phenol. 2. Concentration. It is a white crystalline solid that is volatile. 1976 Oct 16;99(16):319. While previous investigations have concluded that in cats the gene for the phenol-type glucuronosyltransferase isoform has turned into a pseudogene because of several point mutations, evaluation of genomic information for snake species revealed that they have only 2 genes that may code for glucuronosyltransferase isoforms. Acute toxicity (96 h LC50) of phenol was analyzed in the cat fish Mystus vittatus in static bio-assay over a 96-h exposure period using probit method. All forms of phenol cause irritation, and acute toxic effects of phenol most often occur by skin contact. Weaker solutions of phenol (25% to 50%) can be used to achieve lighter peels; however, the results are not better than TCA and there is still the risk for systemic toxicity. Other data on the toxicity of phenol and its derivatives were consistent with the results of the safety evaluation. Examples of such components are phenols. J Am Vet Med Assoc. This organic compound is present in many essential oils, making them unsafe to use around pets especially cats. Cats … Check with your doctor immediately if any of the following side effects occur while taking phenol … Phenol is an aromatic organic compound with the molecular formula C 6 H 5 OH. That is important information for all members. You can taste and smell phenol at levels lower than those that are associated with harmful effects. When compared to dogs, cats are extremely susceptible to phenol toxicity since their liver lacks an important enzyme for metabolism of phenol. Dodman NH, Bogan J, Thompson H. PMID: 982778 [PubMed - indexed for MEDLINE] Publication Types: Methemoglobinemia and hepatotoxicity characterize acetaminophen toxicosis. depends o n it s arom atic ring where benz ene ring itself . Then, when cats groom, they ingest the cleaner which damages their liver and kidneys. Jul 9, 2006 #4 kitytize TCS Member. Recombinant DNA origin human insulin. (1995). Cats are probably a little more sensitive to onion toxicity than dogs are. And that is 1984! can also undergo several chemical reactions such as . Systemic toxicity can result from skin or eye exposures. The hospitalisation period was 1-3 … Cats are more susceptible to salicylate toxicity, because this species is deficient in glucuronidation pathways. Joined Dec 21, 2005 Messages 2,155 Reaction score 2. In cats, toxicity can occur with 10–40 mg/kg. I can't find an exact quantity of onions required to cause toxicity problems in dogs, but there are several case reports of onion toxicity and they involve whole onions or sizable portions of chopped onions (like a cup or more). Basically, the higher the concentration of the essential oil (such as one not diffused with carrier oil), the higher the toxicity. Phenol vapor and liquid penetrate the skin with an absorption efficiency approximately equal to the absorption efficiency by inhalation. I was wondering if anyone here was thinking about toxic substances present in insulin formulations. Treatment in all patients was supportive and symptomatic, and the most commonly used anticonvulsants were diazepam and barbiturates; however, severe unresponsive seizures in three dogs had to be controlled with inhalant gas anaesthesia. Phenol has a distinct odor that is sickeningly sweet and tarry. Here we are – some 33 years later, still questioning if essential oils are killing cats, and reporting all over the place that it is a huge area of concern. Eating garbage or feeding food which is out of date, improperly stored or improperly handled. Last updated on June 14, 2020 Home ... Cats lack the enzymes in their bodies that break down certain components of essential oils. U-40. Phenols . This kind of poisoning causes the stimulation of the nervous system, weakening of the heart and liver damage. The higher the concentration of the essential oil (i.e. Essential oils toxicity in cats: Everything you need to know. It is a colorless-to-white solid when pure. Although hypothermia was very common, especially in cats (90.9%), hyperthermia was frequently observed in dogs (21%). The molecule consists of a phenyl group (−C 6 H 5) bonded to a hydroxy group (−OH). In the case of cats, poisoning happens by absorption through the skin, although ingestion does happen sometimes. PMID: 13697246 [PubMed - indexed for MEDLINE] Because of cats' limited ability to metabolize carprofen via glucuronidation, the drug's elimination half-life (20.1 ± 16.6 hours)21 in that species is longer than in dogs. The cat shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment. Although hypothermia was very common phenol toxicity in cats especially as compared to dogs, cats are deficient in an enzyme called transferase! I was wondering if anyone here was thinking about toxic substances present in insulin.! Some dogs after acetaminophen ingestion TCS member dilute solutions ( 1 % to 2 % ) cause... 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